Sander J, Niehaus C
Dtsch Med Wochenschr. 1980 Jun 6;105(23):827-9. doi: 10.1055/s-2008-1070762.
Dried whole blood of newborn infants on filter paper which is generally used for screening investigations for inborn errors of metabolism has been found suitable in a pilot study for demonstration of rubella antibodies. Investigation of 2522 newborn blood samples using the haemolysis-in-gel test showed lack of rubella specific antibodies of the IgG type in 236 cases. This indicates that 9.3% of mothers had no immunity against rubella. Inclusion of the test into existing newborn screening programmes would permit selective immunisations in the lying in period, discovery of rubella infections within the first months of pregnancy, and permit epidemiological studies. Financial and organisational requirements would be minimal. A considerable improvement in current rubella prophylaxis could thus be achieved.
通常用于筛查先天性代谢缺陷的滤纸上的新生儿干血，在一项风疹抗体检测的初步研究中被发现是合适的。使用凝胶溶血试验对2522份新生儿血样进行检测，结果显示236例缺乏IgG型风疹特异性抗体。这表明9.3%的母亲没有风疹免疫力。将该检测纳入现有的新生儿筛查项目，将有助于在产褥期进行选择性免疫，在怀孕的头几个月发现风疹感染，并开展流行病学研究。资金和组织要求将降至最低。因此，当前的风疹预防措施可得到显著改善。
