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[肾移植后肾皮质的氧供应。犬自体肾移植后肾皮质的氧供应及肾脏血液循环;其对人类肾移植的价值]

[Renocortical oxygen supply after kidney transplantation. Renocortical oxygen supply and kidney circulation after autologous kidney transplantation in the dog; its value for human kidney transplantation].

作者信息

Wilms H

出版信息

Fortschr Med. 1980 Jun 12;98(22):865-8.

PMID:6997155
Abstract

Determination of the viability of a transplanted kidney is still an unsolved problem. Apart from immunological effects hemodynamic and microcirculatory changes in the kidney are important. Thus in 39 mongrel dogs renal floow flow (electromagnetic and local renocortical oxygen supply) and microcirculation (by meaning local tissue pO2) were determined before nephrectomy, immediately after revascularization and before sacrification in experiments with autologous transplantation. Whole kidney blood flow decreased by 30-40%. Measurements of tissue pO2 revealed distinct changes in renocortical oxygen supply. Graft function concomitantly was reduced. Hypotension during revascularization is followed by a strong decrease in renal blood flow and renocortical oxygen supply. Even short periods of hypotension should be avoided.

摘要

确定移植肾的存活能力仍然是一个尚未解决的问题。除免疫效应外,肾脏的血流动力学和微循环变化也很重要。因此,在39只杂种狗的自体移植实验中,在肾切除术前、血管再通后即刻以及处死前,测定了肾血流量(电磁法和局部肾皮质氧供应)和微循环(通过局部组织氧分压测定)。全肾血流量减少了30%-40%。组织氧分压的测量显示肾皮质氧供应有明显变化。移植肾功能随之降低。血管再通期间的低血压会导致肾血流量和肾皮质氧供应大幅下降。即使是短时间的低血压也应避免。

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