Sandahl B, Ulmsten U, Andersson K E
Acta Obstet Gynecol Scand. 1980;59(3):259-60. doi: 10.3109/00016348009155407.
In a randomized, double-blind cross-over study the effect on referred pain of the local anesthetic, ketocaine, was evaluated in 23 women suffering from primary dysmenorrhea. Ketocaine was administered in compresses containing 1 g ketocaine in a 10 per cent ethanol solution. The investigation comprised two consecutive menstrual periods. During one, the patient received ketocaine compresses, and during the other placebo compresses, i.e. compresses without ketocaine. The compresses were applied to the skin area where the patient experienced the most intense pain. When receiving ketocaine compresses, 19 of the 23 patients reported good or moderate pain relief. The effect was recognized within 30 to 60 minutes and lasted for a mean of 3 hours (range 1.5--5 h). Only four of the patients reported relief of pain when receiving placebo compresses. This effect ceased when the compresses were removed. No general side effects were registered. However, erythema at the site of compress application was more often observed after ketocaine than after placebo compresses.
在一项随机、双盲交叉研究中，对23名原发性痛经女性评估了局部麻醉药酮卡因对牵涉痛的影响。酮卡因以含1克酮卡因的10%乙醇溶液制成敷布给药。该研究包括两个连续的月经期。在其中一个月经期，患者接受酮卡因敷布，在另一个月经期接受安慰剂敷布，即不含酮卡因的敷布。敷布敷于患者疼痛最剧烈的皮肤区域。接受酮卡因敷布时，23名患者中有19名报告疼痛得到良好或中度缓解。效果在30至60分钟内显现，平均持续3小时（范围1.5 - 5小时）。接受安慰剂敷布时只有4名患者报告疼痛缓解。敷布移除后这种效果即消失。未记录到全身性副作用。然而，与安慰剂敷布后相比，酮卡因敷布后在敷布应用部位更常观察到红斑。
