Ulmsten U, Sandahl B, Lundén C, Andersson K E
Acta Obstet Gynecol Scand. 1980;59(3):209-12. doi: 10.3109/00016348009155397.
Ketocaine, a new local anesthetic drug, was used for treatment of referred pain during labor. In a randomized, double-blind manner, fifty primigravidae received compresses containing either ketocaine in a 10 per cent ethanol solution or compresses with saline (placebo). The compresses were applied to the skin areas where the patient experienced the most intense pain. Nineteen of the 25 patients receiving ketocaine compresses reported good or moderate pain relief for an average of 2.5 h (range 1--5 h). These patients had a mean cervical dilatation of 3 cm (range 2--5 cm). In patients without effect of the compresses, the cervix was dilated to a mean of 6 cm (range 5--8 cm). In patient reporting good effect of the treatment, pains were located mainly to the back. Only six of the 25 patients receiving placebo compresses obtained relief of pain. The effect ceased immediately upon removal of the compresses. There was no relation between pain relief and the degree of cervical dilatation, or localization of the pain. No maternal or fetal side-effects related to the treatment were registered.
酮卡因，一种新型局部麻醉药，用于治疗分娩时的牵涉痛。采用随机、双盲方式，50名初产妇接受了含有10%乙醇溶液中酮卡因的敷布或生理盐水敷布（安慰剂）。敷布敷于患者疼痛最剧烈的皮肤区域。25名接受酮卡因敷布的患者中有19名报告疼痛得到良好或中度缓解，平均缓解时间为2.5小时（范围1 - 5小时）。这些患者宫颈平均扩张3厘米（范围2 - 5厘米）。敷布无效的患者，宫颈平均扩张至6厘米（范围5 - 8厘米）。报告治疗效果良好的患者，疼痛主要位于背部。25名接受安慰剂敷布的患者中只有6名疼痛得到缓解。敷布移除后效果立即消失。疼痛缓解与宫颈扩张程度或疼痛部位无关。未记录到与治疗相关的母体或胎儿副作用。
