Permin M, Ipsen L, Hansen M K, Andersen L, Petersen E, Rosengreen L, Søfensen M S, Bank D, Steffensen B, Gustafsson B
Z Geburtshilfe Perinatol. 1981 Dec;185(6):360-3.
Pain localized to the lower back in the first stage of labour in 47 primiparous women was treated by epicutaneous application of ketocaine or placebo compresses. Twenty-three patients were treated with ketocaine compresses (Ane-Ped), and 24 patients with compresses soaked with isotonic saline. The pain relieving effect was almost the same in both treatment groups. Pain localized to the lower back was reduced in about 50% of the patients after one hour's application of ketocaine or placebo compresses. Supplementary analgesics had to be administered in about 60% of the patients in each group. No maternal or foetal systemic side effects related to the treatment were registered. Local erythema on the application area was only reported in the ketocaine group. The frequency of feeling of warmth during the application of compresses of ketocaine were high compared to the placebo group, 78% and 29% respectively.
47名初产妇在分娩第一阶段出现下背部疼痛，采用酮卡因或安慰剂敷贴进行经皮治疗。23名患者接受酮卡因敷贴（Ane-Ped）治疗，24名患者接受用等渗盐水浸湿的敷贴治疗。两个治疗组的止痛效果几乎相同。在应用酮卡因或安慰剂敷贴一小时后，约50%的患者下背部疼痛减轻。每组约60%的患者需要使用补充镇痛药。未记录到与治疗相关的母体或胎儿全身副作用。仅在酮卡因组报告了敷贴部位的局部红斑。与安慰剂组相比，应用酮卡因敷贴期间有温热感的频率较高，分别为78%和29%。
