Pettersson L O, Strömbeck J O
Scand J Plast Reconstr Surg. 1978;12(3):287-90. doi: 10.3109/02844317809013007.
An epicutaneously applied solution--A 2358, (Ane-Pad)--containing ketocaine has been used to bring about anaesthesia for dermabrasion in 20 cases. The time of application was 60 min and the amount of ketocaine applied varied from 0.8 to 2.5 g. In order to ensure good contact between the compresses containing the anaesthetic solution and uneven or concave skin surfaces, pressure was applied with the aid of foam plastic. Erythema and oedema were noted as unintended effects. They did not present an inconvenience during the operations or postoperatively. The operation proved to be completely painless for 15 of the patients. None of the remaining 5 patients required complementary anaesthesia, but in one case a slight sensation of pain was evident locally and in 4 cases the patients experienced an intense sensation of warmth.
一种经皮应用的溶液——A 2358（Ane - Pad），含有酮卡因，已用于20例皮肤磨削术的麻醉。应用时间为60分钟，酮卡因的用量在0.8至2.5克之间。为确保含有麻醉溶液的敷料与不平坦或凹陷的皮肤表面良好接触，借助泡沫塑料施加压力。观察到红斑和水肿为意外效应。它们在手术期间或术后并未造成不便。15例患者的手术被证明完全无痛。其余5例患者均无需辅助麻醉，但有1例局部有轻微疼痛感，4例患者有强烈的温热感。
