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脊髓少突胶质细胞瘤

Oligodendrogliomas of the spinal cord.

作者信息

Fortuna A, Celli P, Palma L

出版信息

Acta Neurochir (Wien). 1980;52(3-4):305-29. doi: 10.1007/BF01402086.

Abstract

The clinical, surgical, and pathological data from 35 published cases of oligodendroglioma and of one personal case are analysed and compared with those from other tumours of the cord and from cerebral oligodendrogliomas. Oligodendroglioma of the cord has a slightly lower average age than other gliomas and is closer to that of glioblastoma. In oligodendroglioma of the cord, as of the brain, acute onset or aggravation of the symptoms and an oscillating course are frequent. Two correlated data are particularly worth noting: a) the mean CSF protein content in oligodendroglioma of the cord is higher than in any other glioma; b) intracranial hypertension, in the form of papilloedema or hydrocephalus, or both, was present in 31% of cases. This signifies cerebral oligodendrogliomatosis, which was found in 6 out of 10 necropsied cases. At operation most oligodendrogliomas of the cord appear as infiltrating "gelatinous" tumours, though a minority have a firm consistency and apparently clearcut contours, which seem to be associated with a better prognosis. Postoperative radiotherapy seems to be useful.

摘要

对已发表的35例少突胶质细胞瘤病例及1例个人病例的临床、手术和病理数据进行分析,并与脊髓其他肿瘤及脑少突胶质细胞瘤的数据进行比较。脊髓少突胶质细胞瘤的平均发病年龄略低于其他胶质瘤,更接近胶质母细胞瘤的发病年龄。与脑少突胶质细胞瘤一样,脊髓少突胶质细胞瘤常表现为症状急性发作或加重,病程呈波动状。有两个相关数据尤其值得注意:a)脊髓少突胶质细胞瘤患者脑脊液蛋白含量平均值高于其他任何胶质瘤;b)31%的病例出现视乳头水肿或脑积水形式的颅内高压,或两者皆有。这意味着脑少突胶质细胞瘤病,在10例尸检病例中有6例发现。手术中,大多数脊髓少突胶质细胞瘤表现为浸润性“胶冻状”肿瘤,不过少数质地坚硬,轮廓明显,这似乎与较好的预后相关。术后放疗似乎有效。

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