Chalvardjian A, Picard L, Shaw R, Davey R, Cairns J D
Am J Obstet Gynecol. 1980 Oct 15;138(4):391-4. doi: 10.1016/0002-9378(80)90134-9.
Malacoplakia is an uncommon chronic granulomatous inflammation which most frequently involves the urinary bladder of middle-aged women and rarely affects the genital tract. In this paper 10 cases of female genital malacoplakia are reviewed, seven of which have been reported previously in the literature. Genital malacoplakia usually occurs in women 60 years of age or older and most frequently affects the vagina. Vaginal bleeding is a common presenting complaint and the lesion may simulate a malignancy. Four of the 10 patients were receiving corticosteroids at the time of diagnosis. Escherichia coli was cultured from urine or from the lesion itself in half of the cases. The disease appears to be an acquired defect in bactericidal function of histiocytes. Antibiotic therapy and surgical excision are effective, although a recurrence developed in one patient and was successfully re-excised.
软斑病是一种罕见的慢性肉芽肿性炎症，最常累及中年女性的膀胱，很少影响生殖道。本文回顾了10例女性生殖器软斑病病例，其中7例此前已在文献中报道。生殖器软斑病通常发生在60岁及以上的女性，最常累及阴道。阴道出血是常见的就诊主诉，病变可能类似恶性肿瘤。10例患者中有4例在诊断时正在接受皮质类固醇治疗。半数病例的尿液或病变本身培养出大肠杆菌。该病似乎是组织细胞杀菌功能的后天缺陷。抗生素治疗和手术切除是有效的，尽管有1例患者复发并成功再次切除。
