Pepys M B, Rogers S L
Br J Exp Pathol. 1980 Apr;61(2):156-9.
Mice depleted of circulating C3 by injection of cobra factor (CoF), the C3-activating protein of cobra (Naja naja) venom, mounted the same acute-phase responses of serum amyloid P-component (SAP) to subsequent injection of casein, bacterial lipopolysaccharide or croton oil as did normal control mice. There was also evidence for accelerated synthesis of C3 itself in response to injection of these acute-phase stimulants in CoF-treated mice. On the other hand complement activation produced by injection of CoF alone did not cause any elevation of the serum SAP level. These results indicate that acute-phase plasma protein production can proceed independently of the complement system as a mediator of or participant in inflammatory reactions, and that complement activation alone is not a sufficient stimulus for an acute-phase response, at least of SAP.
通过注射眼镜蛇因子（CoF，眼镜蛇（眼镜蛇属）毒液的C3激活蛋白）使循环C3耗竭的小鼠，对随后注射酪蛋白、细菌脂多糖或巴豆油产生的血清淀粉样P成分（SAP）急性期反应与正常对照小鼠相同。也有证据表明，在CoF处理的小鼠中，注射这些急性期刺激物后，C3自身的合成加速。另一方面，单独注射CoF产生的补体激活并未导致血清SAP水平升高。这些结果表明，急性期血浆蛋白的产生可以独立于补体系统进行，补体系统是炎症反应的介质或参与者，并且单独的补体激活不是急性期反应（至少是SAP的急性期反应）的充分刺激因素。
