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Anti-phalloidine and anti-alpha-amanitine action of silybin in comparison with compounds similar to structural parts of silybin.

作者信息

Trost W, Halbach G

出版信息

Experientia. 1978 Aug 15;34(8):1051-2. doi: 10.1007/BF01915341.

DOI:10.1007/BF01915341
PMID:700023
Abstract

Silybin significantly antagonises the lethal poisoning of mice with alpha-amanitine or phalloidine. In the same test, taxifolin, coniferyl alcohol, fisetin and (+)-catechin were not effective.

摘要

相似文献

1
Anti-phalloidine and anti-alpha-amanitine action of silybin in comparison with compounds similar to structural parts of silybin.
Experientia. 1978 Aug 15;34(8):1051-2. doi: 10.1007/BF01915341.
2
[Anti-phalloidine activity of the silymarins silybine and disilybine].[水飞蓟宾和双水飞蓟宾的抗鬼笔环肽活性]
Arzneimittelforschung. 1975 Mar;25(3):392-3.
3
The action of silybin on the mouse liver in alpha-amanitine poisoning.
Arzneimittelforschung. 1979;29(1):63-8.
4
Prevention of silybin of phalloidin-induced acute hepatoxicity.水飞蓟宾对鬼笔环肽诱导的急性肝毒性的预防作用。
Toxicol Appl Pharmacol. 1979 Nov;51(2):265-75. doi: 10.1016/0041-008x(79)90469-1.
5
Effect of silybin on phalloidin-actin interactions in vitro.
Toxicol Lett. 1982 Apr;11(1-2):111-7. doi: 10.1016/0378-4274(82)90114-x.
6
[Phalloidine antagonists. 1. Effects of silybine derivatives on isolated perfused rat liver].[鬼笔环肽拮抗剂。1. 水飞蓟宾衍生物对离体灌注大鼠肝脏的影响]
Arzneimittelforschung. 1975 Mar;25(3):394-6.
7
[Electronic quantification of experimental hepatic lesions demonstrated by histology (author's transl)].
Arch Anat Cytol Pathol. 1976;24(3):203-9.
8
Possibility of antagonizing experimental poisoning by the toxins of the toadstool Amanita phalloides.拮抗毒鹅膏毒素所致实验性中毒的可能性
Curr Probl Clin Biochem. 1977;7:103-9.
9
[Effect of silymarin on the total dry mass of hepatocytes inacute poisoning by phalloidin and alpha-amanitine (author's transl)].水飞蓟素对鬼笔环肽和α-鹅膏蕈碱急性中毒时肝细胞总干质量的影响（作者译）
Arch Toxicol. 1976 Sep 15;36(1):19-29. doi: 10.1007/BF00277560.
10
[Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology].[水飞蓟宾（来自水飞蓟（Silybum mar. (L) Gaertn.）的抗肝毒性成分）的药效学、作用部位及作用机制。1. 急性毒理学或耐受性、一般及特殊（肝脏）药理学]
Arzneimittelforschung. 1975 Jan;25(1):82-9.

引用本文的文献

1
Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.水飞蓟素成分在丙型肝炎病毒感染中的保肝和抗病毒作用
Hepatology. 2013 Mar;57(3):1262-71. doi: 10.1002/hep.26179.
2
Pharmacokinetic studies on IdB 1016, a silybin- phosphatidylcholine complex, in healthy human subjects.水飞蓟宾-磷脂酰胆碱复合物IdB 1016在健康人体受试者中的药代动力学研究。
Eur J Drug Metab Pharmacokinet. 1990 Oct-Dec;15(4):333-8. doi: 10.1007/BF03190223.

本文引用的文献

1
Amantis. Chemistry and action.
FEBS Lett. 1970 May 11;8(1):1-5. doi: 10.1016/0014-5793(70)80210-1.
2
Peliosis-like changes induced by phalloidin in the rat liver: a light and electron microscopic study.鬼笔环肽诱导大鼠肝脏的类紫癜样改变：光镜和电镜研究
J Med. 1973;4(6):327-45.
3
[Protective action of silymarine in phalloidine intoxication in the mouse].
Agressologie. 1974;15(4):263-70.
4
[Chemistry and pharmacology of silymarin. Studies on various metabolites of silybin].
Arzneimittelforschung. 1974 Jun;24(6):866-7.
5
Proceedings: Relationships between the structure and action of silybin--attempts to neutralize the lethal effects of Amanita phalloides toxins with compounds of silybin type.
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R30.
6
[Phalloidine antagonists. 1. Effects of silybine derivatives on isolated perfused rat liver].[鬼笔环肽拮抗剂。1. 水飞蓟宾衍生物对离体灌注大鼠肝脏的影响]
Arzneimittelforschung. 1975 Mar;25(3):394-6.
7
[Anti-phalloidine activity of the silymarins silybine and disilybine].[水飞蓟宾和双水飞蓟宾的抗鬼笔环肽活性]
Arzneimittelforschung. 1975 Mar;25(3):392-3.
8
[Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology].[水飞蓟宾（来自水飞蓟（Silybum mar. (L) Gaertn.）的抗肝毒性成分）的药效学、作用部位及作用机制。1. 急性毒理学或耐受性、一般及特殊（肝脏）药理学]
Arzneimittelforschung. 1975 Jan;25(1):82-9.
9
[Phalloidin antagonists. 2. Protective effect of disilybine in phalloidin poisoning of isolated hepatocytes].[鬼笔环肽拮抗剂。2. 二氢杨梅素对离体肝细胞鬼笔环肽中毒的保护作用]
Arzneimittelforschung. 1975 Apr;25(4):571-6.