Cooper D K, Charles R G, Fraser R C, Beck W, Barnard C N
Br Med J. 1980 Oct 25;281(6248):1093-6. doi: 10.1136/bmj.281.6248.1093.
Five long-term survivors of heart transplantation were reinvestigated. Two patients had undergone orthotopic heart transplantation over 11 and 9 years earlier and constitute two of the world's longest-surviving patients after this procedure. Three patients had undergone heterotopic heart transplantation (one left heart bypass alone and two biventricular bypass) four to six years earlier. Four of the five patients had had only one or no documented acute rejection episodes. Three had been given blood transfusions. None had had particularly good tissue matching in relation to the donor on HLA typing. All five patients were leading full and active lives. At review two patients had significant coronary artery disease, one severe, presumably due to chronic immune-complex deposition. Heart transplantation remains a major undertaking, but it can offer the patient many years of good-quality life.
对五名心脏移植长期存活者进行了再次调查。两名患者分别在11年和9年前接受了原位心脏移植，是世界上该手术后存活时间最长的两名患者。三名患者在4至6年前接受了异位心脏移植（一名仅进行左心旁路移植，两名进行双心室旁路移植）。五名患者中有四名仅有一次或未记录到急性排斥反应发作。三名患者接受过输血。在HLA分型方面，与供体相比，无一例有特别良好的组织匹配。所有五名患者都过着充实而积极的生活。复查时，两名患者患有严重冠状动脉疾病，一名病情严重，可能是由于慢性免疫复合物沉积所致。心脏移植仍然是一项重大手术，但它可以为患者提供多年的高质量生活。
