Barnard C N, Cooper D K
J R Soc Med. 1981 Sep;74(9):670-4.
The results of the heart transplantation operations performed personally by one surgeon (CNB) at Groote Schuur Hospital between 1967 and 1980 are reviewed. Of 9 orthotopic transplants performed between 1967 and 1973, 4 survived for more than one year and 2 remain alive today twelve and ten years later. Of 11 heterotopic transplants performed since 1974, one-year patient survival has been 82%, though one patient survived on his own heart after irreversible graft rejection. Three of the original 4 patients remain alive over five years later. These results are rather better than the overall results of our unit, where a total of 37 heterotopic transplants has been performed; the possible reasons for this are discussed. One patient, previously unreported, who underwent transplantation of the heart and both lungs in 1971, died after 23 days from pulmonary complications. Heterotopic transplantation using a xenograft (baboon or chimpanzee heart) has been performed on two occasions as a means of temporary circulatory support in patients with acutely failing hearts when no human donor was available. The chimpanzee heart supported the circulation satisfactorily for four days.
本文回顾了1967年至1980年间由一位外科医生（CNB）在格罗特·舒尔医院亲自实施的心脏移植手术结果。1967年至1973年间进行的9例原位移植中，4例存活超过一年，其中2例在十二年后和十年后的今天仍然存活。自1974年以来进行的11例异位移植中，患者一年生存率为82%，不过有1例患者在移植器官发生不可逆排斥反应后依靠自身心脏存活。最初的4例患者中有3例在五年多后仍然存活。这些结果比我们科室的总体结果要好，我们科室共进行了37例异位移植；文中讨论了出现这种情况的可能原因。有1例此前未报告的患者，于1971年接受了心脏和双肺移植，术后23天因肺部并发症死亡。在没有人类供体的情况下，曾两次进行异种移植（狒狒或黑猩猩心脏）作为急性心力衰竭患者的临时循环支持手段。黑猩猩心脏使血液循环得到了四天的良好支持。
