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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Karpati L, Chow F P, Woollard M L, Hutton R A, Dandona P

Clin Sci (Lond). 1980 Nov;59(5):369-72. doi: 10.1042/cs0590369.

Female rats were injected with ethinyloestradiol, norethisterone or both compounds for 30 days. Prostacyclin-like activity was measured in the thoracic aorta and inferior vena cava. 2. In the thoracic aorta of rats injected with ethinyloestradiol and ethinyloestradiol/norethisterone, prostacyclin-like activity was significantly increased. Norethisterone alone had no effect. 3. In the inferior vena cava of rats injected with ethinyloestradiol, norethisterone or both compounds, prostacyclin-like activity was not significantly altered. The amount of prostacyclin generated by the inferior vena cava was much lower than that by the aorta. 4. Experimentally induced changes in the vessel wall after the administration of contraceptive steroids must be due to factors other than diminished prostacyclin production.

给雌性大鼠注射炔雌醇、炔诺酮或这两种化合物30天。测定胸主动脉和下腔静脉中类前列环素活性。2. 在注射炔雌醇和炔雌醇/炔诺酮的大鼠胸主动脉中，类前列环素活性显著增加。单独使用炔诺酮则无作用。3. 在注射炔雌醇、炔诺酮或这两种化合物的大鼠下腔静脉中，类前列环素活性无显著改变。下腔静脉产生的前列环素量远低于主动脉。4. 给予避孕类固醇后血管壁的实验性变化必定归因于除前列环素生成减少之外的其他因素。

Karpati L, Chow F P, Woollard M L, Hutton R A, Dandona P

Clin Sci (Lond). 1980 Nov;59(5):369-72. doi: 10.1042/cs0590369.

Female rats were injected with ethinyloestradiol, norethisterone or both compounds for 30 days. Prostacyclin-like activity was measured in the thoracic aorta and inferior vena cava. 2. In the thoracic aorta of rats injected with ethinyloestradiol and ethinyloestradiol/norethisterone, prostacyclin-like activity was significantly increased. Norethisterone alone had no effect. 3. In the inferior vena cava of rats injected with ethinyloestradiol, norethisterone or both compounds, prostacyclin-like activity was not significantly altered. The amount of prostacyclin generated by the inferior vena cava was much lower than that by the aorta. 4. Experimentally induced changes in the vessel wall after the administration of contraceptive steroids must be due to factors other than diminished prostacyclin production.

给雌性大鼠注射炔雌醇、炔诺酮或这两种化合物30天。测定胸主动脉和下腔静脉中类前列环素活性。2. 在注射炔雌醇和炔雌醇/炔诺酮的大鼠胸主动脉中，类前列环素活性显著增加。单独使用炔诺酮则无作用。3. 在注射炔雌醇、炔诺酮或这两种化合物的大鼠下腔静脉中，类前列环素活性无显著改变。下腔静脉产生的前列环素量远低于主动脉。4. 给予避孕类固醇后血管壁的实验性变化必定归因于除前列环素生成减少之外的其他因素。