Inoue K, Tice L W, Creveling C R
Endocrinology. 1980 Dec;107(6):1833-40. doi: 10.1210/endo-107-6-1833.
Light microscopic immunocytochemical observations of catechol-O-methyl-transferase (COMT) localization in the pregnant rat uterus were made with a specific antibody to soluble rat liver COMT and the peroxidase-antiperoxidase technique. The changes in cellular localization of COMT were followed from the onset of pregnancy to 12 h after delivery of the last fetus. COMT first appeared on day 5 of pregnancy in endometrial epithelial cells of the uterus. On day 7, COMT appeared in the decidual cells on the antimesometrial side of the uterus close to the implanting blastocyst. Two morphologically distinct, COMT-positive, decidual cells were observed: polygonal cells and stellate cells. After parturition, COMT-positive decidual cells remained in the decidua basalis. The possible physiological roles of COMT in the pregnant uterus are discussed.
利用针对可溶性大鼠肝脏儿茶酚-O-甲基转移酶（COMT）的特异性抗体和过氧化物酶-抗过氧化物酶技术，对妊娠大鼠子宫中COMT的定位进行了光镜免疫细胞化学观察。从妊娠开始到最后一只胎儿分娩后12小时，追踪了COMT细胞定位的变化。COMT于妊娠第5天首次出现在子宫的子宫内膜上皮细胞中。在第7天，COMT出现在子宫靠近植入胚泡的反系膜侧的蜕膜细胞中。观察到两种形态不同的COMT阳性蜕膜细胞：多边形细胞和星状细胞。分娩后，COMT阳性蜕膜细胞保留在基蜕膜中。讨论了COMT在妊娠子宫中的可能生理作用。
