各种T细胞功能之间胸腺依赖性的差异。
Differences in thymus-dependency among various T-cell functions.
作者信息
Shimamoto Y, Taniguchi K, Kubo C, Nomoto K
出版信息
Immunology. 1980 Sep;41(1):167-78.
Effects of thymectomy of various times after birth on cytotoxicity, delayed footpad reaction and antibody production were examined in 6 week old mice immunized intraperitoneally with chicken erythrocytes. Cytotoxicity and antibody production were abolished by thymectomy within 3 days after birth. Mice thymectomized at 5 days of age or later showed appreciable degrees of cytotoxicity and antibody production. On the other hand, a delayed footpad reaction could be elicited even in mice thymetocmized within 24 h after birth, although the degree of the reaction was reduced by such a treatment. Therefore, T cells responsible for delayed hypersensitivity were less thymus-dependent and required the presence of the thymus for a shorter period in their development that those responsible for cytotoxicity or antibody production.
对出生后不同时间进行胸腺切除的6周龄小鼠，用鸡红细胞腹腔免疫，检测其细胞毒性、足垫迟发型反应和抗体产生情况。出生后3天内进行胸腺切除可消除细胞毒性和抗体产生。出生5天及以后进行胸腺切除的小鼠表现出相当程度的细胞毒性和抗体产生。另一方面，即使是出生后24小时内进行胸腺切除的小鼠也能引发足垫迟发型反应，尽管这种处理会降低反应程度。因此，负责迟发型超敏反应的T细胞对胸腺的依赖性较小，在其发育过程中需要胸腺存在的时间比负责细胞毒性或抗体产生的T细胞短。
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