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分化的T细胞亚群之间的关系。III. 对异种红细胞迟发型超敏反应的放射抗性。

Relationships among differentiated T-cell subpopulations. III. Radioresistance of delayed hypersensitivity to heterologous erythrocytes.

作者信息

Nomoto K, Taniguchi K, Kubo C, Takeya K

出版信息

Immunology. 1978 Mar;34(3):517-21.

PMID:305892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457605/
Abstract

Effects of whole body irradiation with 600 rad on delayed hypersensitivity, direct cytotoxicity and antibody production were examined in mice immunized with chicken erythrocytes (CRBC) or sheep erythrocytes (SRBC) in saline. Delayed footpad reactions to CRBC were not affected by the exposure to irradiation 3 h before or after antigenic stimulation. On the other hand, direct cytotoxic activities in spleen cells and antibody titres to CRBC were reduced by such exposures. Additionally, delayed footpad reactions to SRBC were not affected by the exposure to irradiation. Generation of effector cells responsible for delayed footpad reactions proved to be resistant to irradiation.

摘要

在用生理盐水悬浮的鸡红细胞（CRBC）或绵羊红细胞（SRBC）免疫的小鼠中，研究了600拉德全身照射对迟发型超敏反应、直接细胞毒性和抗体产生的影响。在抗原刺激前3小时或后进行照射，对CRBC的迟发型足垫反应没有影响。另一方面，这种照射会降低脾细胞中的直接细胞毒性活性以及对CRBC的抗体滴度。此外，对SRBC的迟发型足垫反应不受照射的影响。事实证明，负责迟发型足垫反应的效应细胞的生成对辐射具有抗性。

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