Baltz M L, Dyck R F, Pepys M B
Immunology. 1980 Sep;41(1):59-66.
Amyloid P-component was sought by immunofluorescence in the tissues of CBA mice receiving repeated subcutaneous injections of casein. P-component appeared in a perifollicular distribution in the spleen after about twenty casein injections, and correlated precisely with amyloid deposits identified by staining with Congo red. In mice which had received at least fourteen injections of casein, P-component also became detectable within the cytoplasm of periportal hepatocytes. This is the first demonstration of P-component in murine amyloid and of a possible site for in vivo synthesis of P-component.
通过免疫荧光法在反复皮下注射酪蛋白的CBA小鼠组织中寻找淀粉样P成分。在大约注射20次酪蛋白后,P成分出现在脾脏的滤泡周围,并且与用刚果红染色鉴定的淀粉样沉积物精确相关。在接受了至少14次酪蛋白注射的小鼠中,在门静脉周围肝细胞的细胞质内也可检测到P成分。这是首次在鼠类淀粉样物质中证实P成分以及P成分在体内可能的合成部位。