Zaks A S, Bykova A A
Fiziol Zh SSSR Im I M Sechenova. 1977 Sep;63(9):1319-25.
Specific autoantibodies of neutralizing character to histamine, serotonin, kallikrein, bradykuinine, acetylcholine, adrenalin, noradrenalin, insulin, and to the serotonin metabolite--5-hydroxyindolacetic acid, were found in donor serum (47.2%) and in intact rabbits, guinea pigs, rats, and mice (24.4%). Anti0odies to histamine, serotonin, kallikrein were found in a number of samples of commercial gamma-globulin. They were relatively often observed during the morning and day-time hours, in summer and in winter, in luteal phase of menstrual cycle, early in pregnancy (6-8 weeks), after surgical treatment, burns, inflammation, administration of foreign albumin, in the course of immunization by different antigens. The results of fractional analysis of serum showed that antibodies belonged to immunoglobulins with the constant of sedimantation 7S and 19S. The data obtained suggest the existence of an immune mechanism for the content regulation of different substances of endogenous origination in any organism.
在供体血清（47.2%）以及健康的兔、豚鼠、大鼠和小鼠（24.4%）中发现了对组胺、血清素、激肽释放酶、缓激肽、乙酰胆碱、肾上腺素、去甲肾上腺素、胰岛素以及血清素代谢物——5-羟吲哚乙酸具有中和特性的特异性自身抗体。在许多商业γ-球蛋白样本中发现了针对组胺、血清素、激肽释放酶的抗体。它们在早晨和白天、夏季和冬季、月经周期的黄体期、妊娠早期（6 - 8周）、手术治疗后、烧伤、炎症、注射异体白蛋白后以及用不同抗原免疫过程中相对经常出现。血清分级分析结果表明，这些抗体属于沉降常数为7S和19S的免疫球蛋白。所获得的数据表明，在任何生物体中存在一种免疫机制来调节内源性不同物质的含量。
