Sergeev P V, Denisov Iu P
Farmakol Toksikol. 1978 Sep-Oct;41(5):597-601.
By using fluorescent probes it was shown that hydrocortisone, cortisone and estron decrease the constant of the probe binding with dimethylaminochalcone in the lipid membranes proportional to the distribution coefficient of steroids in the system lipids-water. It is only hydrocortisone and, to a lesser extent, cortisone which produce such an effect in the plasmatic membranes of the hepasytes. The presence of a "preference system" for corticosteroids is presumed in the membranes.
通过使用荧光探针表明，氢化可的松、可的松和雌酮会降低探针与脂质膜中二甲氨基查耳酮结合的常数，其降低程度与类固醇在脂质 - 水体系中的分配系数成正比。只有氢化可的松，以及在较小程度上可的松，会在肝细胞的质膜中产生这种效应。推测在膜中存在对皮质类固醇的“偏好系统”。
