Webb J L
J Reprod Med. 1980 Oct;25(4):150-6.
Oral contraceptives agents (OCA) have been in use for more than two decades, and at the present time, 150 to 200 million women are using the preparations. Apart from their gynecologic influence, the hormones have been shown to affect a number of metabolic and nutritional processes, some advantageously and others disadvantageously. Concern over the nutritional status of females consuming OCA prompted this review. Eight vitamins and three minerals were investigated. Contraceptive steroid ingestion was shown to depress the physiologic levels of six nutrients (riboflavin, pyridoxine, folacin, vitamin B12, ascorbic acid and zinc), elevate the levels of three others (vitamin K, iron and copper) and provide little or no change in one (alpha tocopherol) and questionable increases in another (vitamin A). It was concluded that females consuming OCA should pay particular attention to vitamin and mineral intake and, if warranted, consume physiologic supplements of needed nutrients.
口服避孕药已经使用了二十多年，目前有1.5亿至2亿女性在使用这类制剂。除了对妇科方面的影响外，这些激素已被证明会影响许多代谢和营养过程，有些是有益的，有些则是不利的。对服用口服避孕药的女性营养状况的关注促使了本次综述。研究了八种维生素和三种矿物质。结果显示，摄入避孕类固醇会降低六种营养素（核黄素、吡哆醇、叶酸、维生素B12、抗坏血酸和锌）的生理水平，提高另外三种营养素（维生素K、铁和铜）的水平，对一种营养素（α-生育酚）几乎没有影响或没有变化，对另一种营养素（维生素A）的影响则存在疑问。结论是，服用口服避孕药的女性应特别注意维生素和矿物质的摄入，并在必要时服用所需营养素的生理补充剂。
