系统性红斑狼疮中前列环素活性降低。
Reduced prostacyclin activity in systemic lupus erythematosus.
作者信息
McVerry B A, Machin S J, Parry H, Goldstone A H
出版信息
Ann Rheum Dis. 1980 Oct;39(5):524-5. doi: 10.1136/ard.39.5.524.
Abstract
When fresh rabbit aorta is incubated with plasma, prostacyclin, a potent inhibitor of platelet aggregation, is normally released. Plasma obtained from 2 patients with systemic lupus erythematosus (SLE) inhibited prostacyclin activity, while plasma from 22 other patients with SLE and 40 normal control subjects showed normal activity. Absence of prostacyclin activity did not appear to correlate with the clinical severity of the underlying disease. The possible association of this finding and the presence of thrombotic lesions in both patients is discussed.
摘要
当新鲜兔主动脉与血浆一起孵育时，通常会释放出前列环素，一种有效的血小板聚集抑制剂。从2例系统性红斑狼疮（SLE）患者获得的血浆抑制了前列环素活性，而来自其他22例SLE患者和40名正常对照者的血浆显示出正常活性。前列环素活性的缺乏似乎与基础疾病的临床严重程度无关。讨论了这一发现与两名患者血栓性病变存在之间的可能关联。
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本文引用的文献
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Thrombosis of renal veins and inferior vena cava complicating lupus nephritis.狼疮性肾炎并发肾静脉和下腔静脉血栓形成。
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An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.从动脉中分离出的一种酶可将前列腺素内过氧化物转化为一种抑制血小板聚集的不稳定物质。
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Haemolytic-uraemic syndrome: deficiency of plasma factor(s) regulating prostacyclin activity?溶血尿毒综合征：调节前列环素活性的血浆因子缺乏？
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Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation.人体动脉和静脉组织会产生前列环素（前列腺素X），这是一种有效的血小板聚集抑制剂。
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