狼疮抗凝物、肺血栓栓塞与致命性肺动脉高压。

Anderson N E, Ali M R

Ann Rheum Dis. 1984 Oct;43(5):760-3. doi: 10.1136/ard.43.5.760.

A patient with a circulating lupus anticoagulant in the absence of systemic lupus erythematosus developed recurrent deep venous thromboses and pulmonary emboli. Pulmonary emboli recurred despite prolonged oral anticoagulant therapy and resulted in fatal pulmonary arterial hypertension. Extended anticoagulant therapy alone may not prevent recurrent thromboembolism in patients with a lupus anticoagulant. Pulmonary thromboembolism may be an important factor in the pathogenesis of pulmonary hypertension in patients with a lupus anticoagulant.

一名无系统性红斑狼疮但存在循环狼疮抗凝物的患者出现复发性深静脉血栓形成和肺栓塞。尽管进行了长期口服抗凝治疗，肺栓塞仍复发，并导致致命性肺动脉高压。单纯延长抗凝治疗可能无法预防狼疮抗凝物患者的复发性血栓栓塞。肺血栓栓塞可能是狼疮抗凝物患者肺动脉高压发病机制中的一个重要因素。