Heddle R J, Kwitko A O, Shearman D J
Clin Exp Immunol. 1980 Sep;41(3):453-8.
Evidence of an abnormality of IgM- and IgG-specific antibody responses was sought in subjects with selective IgA deficiency. Twenty-four patients having a serum IgA level less than 0 . 37 g/l were detected by local-population screening. Total IgM and IgG levels were measured as well as specific antibody to the lipopolysaccharides of six 0 serotypes of E. coli which are frequently isolated from human faeces. Serum IgM-class E. coli antibodies were significantly lower in IgA-deficient patients than in age- and sex-matched controls. The respective IgG-class antibody was generally elevated although more variation existed in this class. There was no correlation of specific antibody in either class with the degree of IgA deficiency. Possible explanations for these patterns of antibody response are discussed. It is concluded that some subjects with 'selective IgA deficiency' may be deficient in specific IgM antibody responses to certain antigens.
在选择性IgA缺乏症患者中寻找IgM和IgG特异性抗体反应异常的证据。通过当地人群筛查发现了24例血清IgA水平低于0.37g/l的患者。检测了总IgM和IgG水平以及针对六种经常从人类粪便中分离出的大肠杆菌O血清型脂多糖的特异性抗体。IgA缺乏症患者的血清IgM类大肠杆菌抗体明显低于年龄和性别匹配的对照组。相应的IgG类抗体通常升高，尽管该类抗体存在更多变异。两类特异性抗体与IgA缺乏程度均无相关性。讨论了这些抗体反应模式的可能解释。得出的结论是，一些“选择性IgA缺乏症”患者可能缺乏对某些抗原的特异性IgM抗体反应。
