Pujalte J M, Llavore E P, Ylescupidez F R
Curr Med Res Opin. 1980;7(2):110-14. doi: 10.1185/03007998009112036.
The efficacy and tolerance of oral glucosamine sulphate were tested against placebo in a prospective double-blind trial in 20 out-patients with established osteoarthrosis. Two capsules of either glucosaminene sulphate (250 mg) or placebo were administered 3-times daily over a period of 6 to 8 weeks. Articular pain, joint tenderness and restricted movement were semi-quantitatively scored 1 to 4 every 3 days, and individually averaged over the treatment period (overall composite score). Possible side-reactions were similarly scored upon positive questioning of the patients. Haematology, erythrocyte sedimentation rate, urine analysis and X-rays were recorded before and after treatment. Significant alleviation of symptoms was associated with the use of the active drug at the prescribed dose. Similarly, patients given glucosamine sulphate experienced earlier alleviation of symptoms compared with those who had placebo. The use of glucosamine sulphate also resulted in a significantly larger proportion of patients who experienced lessening or disappearance of symptoms within the trial period. No adverse reactions were reported by the patients treated with glucosamine, and no variation in laboratory tests was recorded.
在一项前瞻性双盲试验中，对20名确诊为骨关节炎的门诊患者进行了口服硫酸葡萄糖胺与安慰剂的疗效及耐受性对比测试。硫酸葡萄糖胺（250毫克）胶囊或安慰剂胶囊，每日服用3次，持续6至8周。每3天对关节疼痛、关节压痛和活动受限进行1至4级的半定量评分，并在治疗期间计算个体平均得分（总体综合评分）。通过对患者进行阳性询问，对可能出现的副作用进行类似评分。记录治疗前后的血液学、红细胞沉降率、尿液分析及X光检查结果。按规定剂量使用活性药物可显著缓解症状。同样，与服用安慰剂的患者相比，服用硫酸葡萄糖胺的患者症状缓解得更早。使用硫酸葡萄糖胺还使得在试验期内症状减轻或消失的患者比例显著更高。服用硫酸葡萄糖胺的患者未报告有不良反应，实验室检查也未记录到变化。
