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1
Hidden Thy-1 antigen in a subpopulation of mouse bone marrow cells.小鼠骨髓细胞亚群中隐藏的甲状腺-1抗原。
Immunology. 1980 Mar;39(3):375-84.
2
Many cells in rat bone marrow have cell-surface Thy-1 antigen.大鼠骨髓中的许多细胞都有细胞表面的Thy-1抗原。
Eur J Immunol. 1976 Jul;6(7):526-8. doi: 10.1002/eji.1830060716.
3
Thy-1 determinants are present on many murine hematopoietic cells other than T cells.Thy-1决定簇存在于许多除T细胞之外的小鼠造血细胞上。
Eur J Immunol. 1982 May;12(5):359-64. doi: 10.1002/eji.1830120502.
4
Demonstration of Thy-1 antigen on pluripotent hemopoietic stem cells in the rat.大鼠多能造血干细胞上Thy-1抗原的显示
J Exp Med. 1978 Nov 1;148(5):1351-66. doi: 10.1084/jem.148.5.1351.
5
Terminal deoxynucleotidyl transferase is found in prothymocytes.末端脱氧核苷酸转移酶存在于前胸腺细胞中。
J Exp Med. 1976 Aug 1;144(2):543-8. doi: 10.1084/jem.144.2.543.
6
T cell regulation of interferon-alpha/beta (IFN-alpha/beta) production by alloantigen-stimulated bone marrow cells.T细胞对同种抗原刺激的骨髓细胞产生α/β干扰素（IFN-α/β）的调节作用。
J Immunol. 1985 May;134(5):3137-41.
7
Pluripotential hematopoietic stem cells in post-5-fluorouracil murine bone marrow express the Thy-1 antigen.5-氟尿嘧啶处理后的小鼠骨髓中的多能造血干细胞表达Thy-1抗原。
J Immunol. 1985 Aug;135(2):1004-11.
8
The presence of Thy-1 on the surface of rat lymphoid stem cells and colony-forming units.
Eur J Immunol. 1979 Nov;9(11):853-9. doi: 10.1002/eji.1830091105.
9
Ly-4.2: a cell membrane alloantigen of murine B lymphocytes. I. Population studies.Ly-4.2：小鼠B淋巴细胞的一种细胞膜同种异体抗原。I. 群体研究。
J Immunol. 1975 Feb;114(2 pt 2):848-55.
10
A new Thy-1 alloantigen as a temporal marker of T lymphocyte differentiation.
Nature. 1978 Oct 26;275(5682):711-5. doi: 10.1038/275711a0.

引用本文的文献

1
Association of thy-1 cell surface differentiation antigen with certain connective tissues in vivo.体内Thy-1细胞表面分化抗原与某些结缔组织的关联。
Cell Tissue Res. 1980;206(3):459-75. doi: 10.1007/BF00237975.
2
Analysis of rat hemopoietic cells on the fluorescence-activated cell sorter. I. Isolation of pluripotent hemopoietic stem cells and granulocyte-macrophage progenitor cells.利用荧光激活细胞分选仪分析大鼠造血细胞。I. 多能造血干细胞和粒细胞-巨噬细胞祖细胞的分离。
J Exp Med. 1980 Aug 1;152(2):419-37. doi: 10.1084/jem.152.2.419.
3
Expression of Thy-1 antigen is not limited to T cells in cultures of mouse hemopoietic cells.在小鼠造血细胞培养物中，Thy-1抗原的表达并不局限于T细胞。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4161-5. doi: 10.1073/pnas.79.13.4161.
4
Sequential activation and loss of the pre-B cell Thy-1 gene in T-cell X pre-B cell somatic hybrids.T细胞与前B细胞体细胞杂交体中前B细胞Thy-1基因的顺序激活与缺失
Immunogenetics. 1988;27(5):313-21. doi: 10.1007/BF00395126.
5
Differential regulation of a Thy-1 gene in transgenic mice.转基因小鼠中Thy-1基因的差异调控。
Proc Natl Acad Sci U S A. 1987 Mar;84(6):1492-6. doi: 10.1073/pnas.84.6.1492.
6
Cyclosporin A prevents the in vivo development of murine prothymocytes from uncommitted (Thy-1-) precursor cells.环孢素A可阻止未定向（Thy-1-）前体细胞来源的小鼠前胸腺细胞在体内发育。
Immunology. 1989 Dec;68(4):564-9.
7
Determination of the molecular nature and cellular localization of Thy-1 in human renal tissue.人肾组织中Thy-1的分子性质及细胞定位的测定
Immunology. 1990 Mar;69(3):391-5.

本文引用的文献

1
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
J Exp Med. 1964 Sep 1;120(3):413-33. doi: 10.1084/jem.120.3.413.
2
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells.正常小鼠骨髓细胞辐射敏感性的直接测量。
Radiat Res. 1961 Feb;14:213-22.
3
The separation of different cell classes from lymphoid organs. II. The purification and analysis of lymphocyte populations by equilibrium density gradient centrifugation.从淋巴器官中分离不同细胞类别。II. 通过平衡密度梯度离心法对淋巴细胞群体进行纯化与分析。
Aust J Exp Biol Med Sci. 1968 Aug;46(4):375-96. doi: 10.1038/icb.1968.32.
4
Absorption of guinea pig serum with agar. A method for elimination of itscytotoxicity for murine thymus cells.用琼脂吸收豚鼠血清。一种消除其对小鼠胸腺细胞细胞毒性的方法。
Transplantation. 1970 Jul;10(1):130-2. doi: 10.1097/00007890-197007000-00027.
5
Brain-associated stem cell antigen: an antigen shared by brain and hemopoietic stem cells.脑相关干细胞抗原：一种脑和造血干细胞共有的抗原。
J Exp Med. 1972 Aug 1;136(2):369-74. doi: 10.1084/jem.136.2.369.
6
A rat analog of the mouse theta antigen.一种小鼠θ抗原的大鼠类似物。
Transplant Proc. 1973 Mar;5(1):79-82.
7
Estimation of the amount and tissue distribution of rat Thy-1.1 antigen.大鼠Thy-1.1抗原含量及组织分布的测定
Eur J Immunol. 1974 Sep;4(9):598-602. doi: 10.1002/eji.1830040904.
8
Induction of T-cell differentiation in vitro by thymin, a purified polypeptide hormone of the thymus.胸腺素（一种纯化的胸腺多肽激素）在体外诱导T细胞分化。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1474-8. doi: 10.1073/pnas.71.4.1474.
9
Studies on thymus products. VI. The effects of cyclic nucleotides and prostaglandins on rosette-forming cells. Interactions with thymic factor.
Eur J Immunol. 1973 Dec;3(12):778-83. doi: 10.1002/eji.1830031208.
10
Differentiation of T cells induced by preparations from thymus and by nonthymic agents.胸腺制剂及非胸腺因子诱导的T细胞分化
J Exp Med. 1973 Oct 1;138(4):1027-32. doi: 10.1084/jem.138.4.1027.

小鼠骨髓细胞亚群中隐藏的甲状腺-1抗原。

Hidden Thy-1 antigen in a subpopulation of mouse bone marrow cells.

作者信息

Ritter M A, Morris R J, Goldschneider I

出版信息

Immunology. 1980 Mar;39(3):375-84.

PMID:7002765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457790/
Abstract

Immunofluorescence and cytolysis studies using antisera against the xeno- and alloantigenic components of the Thy-1 molecule have shown that in adult mouse bone marrow more cells bear the xeno than the alloantigen. Allo+ cells form a subset of a larger, xeno+ population. Xeno+ allo- 'prothymocytes' can be induced to express the alloantigen in vitro; this could result from the unmasking of cryptic antigen, the presence of which is demonstrated, rather than de novo antigen synthesis. Some xeno+ allo- cells are involved in splenic haemopoiesis, either as a subpopulation of precursors, or as accessory helper cells.

摘要

使用针对Thy-1分子的异种和同种异体抗原成分的抗血清进行的免疫荧光和细胞溶解研究表明，在成年小鼠骨髓中，携带异种抗原的细胞比携带同种异体抗原的细胞更多。同种异体抗原阳性（Allo+）细胞形成了一个更大的异种抗原阳性（Xeno+）群体的一个子集。异种抗原阳性、同种异体抗原阴性（Xeno+ allo-）的“原胸腺细胞”可在体外被诱导表达同种异体抗原；这可能是由于隐蔽抗原的暴露，已证实其存在，而非从头合成抗原。一些Xeno+ allo-细胞参与脾脏造血，要么作为前体细胞亚群，要么作为辅助性辅助细胞。