小鼠骨髓细胞亚群中隐藏的甲状腺-1抗原。
Hidden Thy-1 antigen in a subpopulation of mouse bone marrow cells.
作者信息
Ritter M A, Morris R J, Goldschneider I
出版信息
Immunology. 1980 Mar;39(3):375-84.
Abstract
Immunofluorescence and cytolysis studies using antisera against the xeno- and alloantigenic components of the Thy-1 molecule have shown that in adult mouse bone marrow more cells bear the xeno than the alloantigen. Allo+ cells form a subset of a larger, xeno+ population. Xeno+ allo- 'prothymocytes' can be induced to express the alloantigen in vitro; this could result from the unmasking of cryptic antigen, the presence of which is demonstrated, rather than de novo antigen synthesis. Some xeno+ allo- cells are involved in splenic haemopoiesis, either as a subpopulation of precursors, or as accessory helper cells.
摘要
使用针对Thy-1分子的异种和同种异体抗原成分的抗血清进行的免疫荧光和细胞溶解研究表明，在成年小鼠骨髓中，携带异种抗原的细胞比携带同种异体抗原的细胞更多。同种异体抗原阳性（Allo+）细胞形成了一个更大的异种抗原阳性（Xeno+）群体的一个子集。异种抗原阳性、同种异体抗原阴性（Xeno+ allo-）的“原胸腺细胞”可在体外被诱导表达同种异体抗原；这可能是由于隐蔽抗原的暴露，已证实其存在，而非从头合成抗原。一些Xeno+ allo-细胞参与脾脏造血，要么作为前体细胞亚群，要么作为辅助性辅助细胞。
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