米安色林：治疗剂量范围的确定
Mianserin: determination of therapeutic dose range.
作者信息
Petrie W M, Wilson W H, Ban T A, Guy W, Schaffer J D
出版信息
Int Pharmacopsychiatry. 1980;15(2):111-7. doi: 10.1159/000468421.
Mianserin hydrochloride is a tetracyclic antidepressant with an EEG and clinical activity profile similar to amitriptyline. To investigate the drug's optimal dosage range, a 6-week open comparative trial sequentially assigned 12 depressed patients to one of three dose ranges (60, 90 and 120 mg). Improvement occurred in depressive symptomatology in all three treatment groups. There was no differential improvement noted in any group; however, the incidence of adverse effects was greater in the middle (90 mg) and high (120 mg) dose ranges.
盐酸米安色林是一种四环类抗抑郁药，其脑电图和临床活性特征与阿米替林相似。为了研究该药物的最佳剂量范围，进行了一项为期6周的开放性对照试验，将12名抑郁症患者依次分配到三个剂量范围（60、90和120毫克）之一。所有三个治疗组的抑郁症状均有改善。各治疗组之间未观察到改善程度的差异；然而，中等剂量（90毫克）和高剂量（120毫克）范围的不良反应发生率更高。
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