米安色林治疗门诊抑郁症患者的安慰剂对照研究。
Placebo-controlled study of mianserin in depressed outpatients.
作者信息
McGrath P J, Rabkin J G, Stewart J W, Harrison W, Quitkin F M, Markowitz J
出版信息
Neuropsychobiology. 1985;14(3):128-32. doi: 10.1159/000118218.
Ninety-two outpatients with depressive disorders which met Research Diagnostic Criteria were treated either with mianserin or placebo in a 6-week controlled trial. Twenty-four of 42 (57%) mianserin-treated patients were rated responders to mianserin treatment while 15 of 50 (30%) were rated responders to placebo treatment (chi 2 = 6.89, p less than 0.01). This rate of drug response was comparable to that achieved with a tricyclic antidepressant in a similar study done in our clinic, supporting the use of mianserin in mildly depressed outpatients.
92名符合研究诊断标准的抑郁症门诊患者在一项为期6周的对照试验中，接受了米安色林或安慰剂治疗。42名接受米安色林治疗的患者中有24名（57%）被评定为对米安色林治疗有反应，而50名接受安慰剂治疗的患者中有15名（30%）被评定为对安慰剂治疗有反应（卡方 = 6.89，p < 0.01）。这种药物反应率与我们诊所进行的一项类似研究中使用三环类抗抑郁药所达到的反应率相当，支持米安色林在轻度抑郁门诊患者中的应用。
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