Kelly M C, Denburg J A
Department of Medicine, McMaster University, Hamilton, ON, Canada.
J Rheumatol. 1987 Aug;14(4):740-4.
Neuronal antibodies found in the cerebrospinal fluid (CSF) of patients with systemic lupus erythematosus (SLE) may be locally produced, or may enter through a damaged blood-brain barrier. We measured CSF serum/albumin and IgG ratios, oligoclonal banding, and paired CSF/serum neuronal antibody in 36 patients and 98 controls. Only 14% of SLE CSF contained neuronal antibodies; 80% of these had clinically overt neuropsychiatric manifestations. None of 73 patients with noninflammatory central nervous system (CNS) disease had CSF-neuronal antibodies, compared with 8/61 with SLE or related inflammatory CNS disorders (p less than .001). In SLE, CSF neuronal antibodies were accompanied by high titer serum neuronal antibodies (p less than 0.03) or abnormal Q-albumin and occurred only when serum neuronal antibodies were present. CSF-neuronal antibodies appear to be related to immune-inflammatory CNS disease, especially SLE, and may traverse a damaged blood-brain barrier.
在系统性红斑狼疮（SLE）患者脑脊液（CSF）中发现的神经元抗体可能是局部产生的，也可能通过受损的血脑屏障进入。我们检测了36例患者和98例对照的脑脊液血清/白蛋白和IgG比值、寡克隆带以及配对的脑脊液/血清神经元抗体。只有14%的SLE脑脊液含有神经元抗体；其中80%有临床明显的神经精神表现。73例非炎性中枢神经系统（CNS）疾病患者的脑脊液中均无神经元抗体，而61例SLE或相关炎性CNS疾病患者中有8例有（p<0.001）。在SLE中，脑脊液神经元抗体伴有高滴度血清神经元抗体（p<0.03）或异常Q-白蛋白，且仅在血清神经元抗体存在时出现。脑脊液神经元抗体似乎与免疫炎性CNS疾病有关，尤其是SLE，并且可能穿过受损的血脑屏障。
