Grange J M, Gibson J, Nassau E, Kardjito T
Tubercle. 1980 Sep;61(3):145-52. doi: 10.1016/0041-3879(80)90003-3.
Enzyme-linked immunosorbent assay (ELISA) has been used to study the levels of antibody binding to the soluble antigens of Mycobacterium tuberculosis (BCG) in the IgG, IgM and IgA classes in sera from patients with tuberculosis, sarcoidosis and Crohn's disease. Of the patients with tuberculosis, 75% had significantly elevated levels of anti-M. tuberculosis antibodies in the IgG class. The levels of antibodies in the IgM and IgA classes were much less discriminative. Many of the patients with sarcoidosis and Crohn's disease had significantly elevated levels of antimycobacterial antibodies, principally in the IgM and IgA classes. These elevated levels of antibody were not related to the total levels of the immunoglobulin classes. For the purpose of serodiagnosis, an estimation of the antimycobacterial antibodies in the IgG class gives the most discriminative results.
酶联免疫吸附测定（ELISA）已被用于研究结核病、结节病和克罗恩病患者血清中IgG、IgM和IgA类抗体与结核分枝杆菌（卡介苗）可溶性抗原的结合水平。在结核病患者中，75%的患者IgG类抗结核分枝杆菌抗体水平显著升高。IgM和IgA类抗体水平的鉴别性则低得多。许多结节病和克罗恩病患者的抗分枝杆菌抗体水平显著升高，主要是IgM和IgA类。这些升高的抗体水平与免疫球蛋白类的总水平无关。为了进行血清学诊断，对IgG类抗分枝杆菌抗体的评估给出的鉴别结果最具判别力。
