可乐定、胍乙啶和呋塞米对大鼠血管升压素性高血压发展的影响。
Effects of clonidine, guanethidine and furosemide on the development of vasopressin hypertension in rat.
作者信息
Szadowska A, Kamińska A
出版信息
Acta Physiol Pol. 1980 Jul-Aug;31(4):409-16.
PMID:7004088
Abstract
The influence of clonidine, guanethidine and furosemide on the development of arterial hypertension was studied in rats with hypertension induced by repeated administration of lysine vasopressin. It was found that these drugs administered during long time periods together with lysine vasopressin prevented the development of arterial hypertension. When any of these drugs was given in combination with vasopressin plasma renin activity failed to rise and the level and turnover of catecholamines in rat brain were unchanged.
摘要
在通过反复给予赖氨酸加压素诱导高血压的大鼠中，研究了可乐定、胍乙啶和呋塞米对动脉高血压发展的影响。发现这些药物在长时间与赖氨酸加压素一起给药时可预防动脉高血压的发展。当这些药物中的任何一种与加压素联合使用时，血浆肾素活性未能升高，且大鼠脑中儿茶酚胺的水平和周转率未发生变化。
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