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胰岛素依赖型糖尿病中的残余胰岛素分泌

Residual insulin secretion in insulin dependent diabetes mellitus.

作者信息

Rogers S, Silink M

出版信息

Arch Dis Child. 1985 Mar;60(3):200-3. doi: 10.1136/adc.60.3.200.

DOI:10.1136/adc.60.3.200
PMID:3885867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1777172/
Abstract

The residual insulin secretory capacity of 244 children with insulin dependent diabetes mellitus was determined by measurement of their 24 hour urinary C peptide excretion. An inverse linear relation was found between the residual B cell secretion and the duration of diabetes. The age at onset of diabetes did not affect the residual B cell function significantly.

摘要

通过测量244名胰岛素依赖型糖尿病患儿24小时尿C肽排泄量，测定了他们的残余胰岛素分泌能力。发现残余B细胞分泌与糖尿病病程之间呈负线性关系。糖尿病发病年龄对残余B细胞功能无显著影响。

相似文献

1
Residual insulin secretion in insulin dependent diabetes mellitus.胰岛素依赖型糖尿病中的残余胰岛素分泌
Arch Dis Child. 1985 Mar;60(3):200-3. doi: 10.1136/adc.60.3.200.
2
Residual insulin secretion in insulin dependent diabetes mellitus.胰岛素依赖型糖尿病中的残余胰岛素分泌
Arch Dis Child. 1986 May;61(5):527-8. doi: 10.1136/adc.61.5.527-a.
3
[C-peptide excretion in 24 hours-urine as an indicator of B-cell residual function in children and adolescents with type-I-diabetes (author's transl)].24小时尿C肽排泄作为1型糖尿病儿童和青少年B细胞残余功能指标（作者译）
Monatsschr Kinderheilkd. 1982 Apr;130(4):209-14.
4
Urinary C-peptide excretion at onset of insulin dependent diabetes mellitus in children.儿童胰岛素依赖型糖尿病发病时的尿C肽排泄情况。
Acta Paediatr Scand. 1987 Jul;76(4):608-11. doi: 10.1111/j.1651-2227.1987.tb10529.x.
5
[Studies on urinary C-peptide excretion in normal children and children with insulin-dependent diabetes mellitus].[正常儿童和胰岛素依赖型糖尿病儿童尿C肽排泄的研究]
Nihon Ika Daigaku Zasshi. 1989 Apr;56(2):103-22. doi: 10.1272/jnms1923.56.103.
6
Residual B-cell function in insulin dependent (Type 1) and non insulin-dependent (Type 2) diabetics (relationship between 24-hour C-peptide excretion and the clinical features of diabetes).胰岛素依赖型（1型）和非胰岛素依赖型（2型）糖尿病患者的残余B细胞功能（24小时C肽排泄与糖尿病临床特征之间的关系）
Diabete Metab. 1983 Sep;9(3):183-7.
7
[Residual insulin secretion in juvenile diabetes. Relationships with duration of diabetes, metabolic control and retinopathy (author's transl)].青少年糖尿病中的残余胰岛素分泌。与糖尿病病程、代谢控制及视网膜病变的关系（作者译）
Arch Fr Pediatr. 1982 Mar;39(3):145-8.
8
Correlation between fasting serum C-peptide and B cell insulin secretory capacity in diabetes mellitus.
Diabetologia. 1982 Apr;22(4):296. doi: 10.1007/BF00281310.
9
[Evaluation of preserved insulin secretion in children and adolescents with type 1 diabetes].[1型糖尿病儿童和青少年中胰岛素分泌保留情况的评估]
Pediatr Endocrinol Diabetes Metab. 2010;16(2):67-71.
10
[Assay of C-peptide in diabetes in children and adolescents].[儿童及青少年糖尿病患者C肽检测]
Ann Med Interne (Paris). 1984;135(6):416-9.

引用本文的文献

1
Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second-phase insulin secretion.差异磷酸化的 RhoGDI 调节 Cdc42 和 Rac1 的循环，从而调节第二阶段胰岛素分泌。
J Biol Chem. 2010 Feb 26;285(9):6186-97. doi: 10.1074/jbc.M109.072421. Epub 2009 Dec 22.
2
Residual insulin production, glycaemic control and prevalence of microvascular lesions and polyneuropathy in long-term type 1 (insulin-dependent) diabetes mellitus.长期1型（胰岛素依赖型）糖尿病患者的残余胰岛素分泌、血糖控制情况以及微血管病变和多发性神经病变的患病率
Diabetologia. 1987 Apr;30(4):208-13. doi: 10.1007/BF00270417.
3
Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis.
Diabetologia. 1988 Sep;31(9):664-9. doi: 10.1007/BF00278749.

本文引用的文献

1
Residual beta-cell function and islet cell antibodies in diabetic children.
Pediatr Res. 1981 Jan;15(1):62-5. doi: 10.1203/00006450-198101000-00015.
2
Urine C-peptide, beta-cell function, and insulin requirement.尿C肽、β细胞功能与胰岛素需求量。
Am J Dis Child. 1980 Dec;134(12):1129-33. doi: 10.1001/archpedi.1980.02130240013006.
3
Insulin biosynthesis and C-peptide. Practical applications from basic research.
Am J Dis Child. 1980 Dec;134(12):1119-21.
4
Residual B cell function in diabetic children as determined by urinary C-peptide.通过尿C肽测定糖尿病儿童的残余B细胞功能。
Diabetologia. 1983 Feb;24(2):88-90. doi: 10.1007/BF00297387.
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Urinary C-peptide: a simple measure of integrated insulin production with emphasis on the effects of body size, diet, and corticosteroids.
J Clin Endocrinol Metab. 1983 Jan;56(1):60-7. doi: 10.1210/jcem-56-1-60.
6
Partial preservation of pancreatic beta-cell function in children with diabetes.糖尿病患儿胰腺β细胞功能的部分保留
Lancet. 1981 Jul 4;2(8236):1-4. doi: 10.1016/s0140-6736(81)90249-x.
7
C-peptide in children with juvenile diabetes. A preliminary report.青少年糖尿病患儿的C肽。初步报告。
Diabetologia. 1976 Dec;12(6):627-30. doi: 10.1007/BF01220642.
8
Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas.通过外部人工胰腺实现青少年糖尿病的持续胰岛素诱导缓解。
Diabetologia. 1978 Apr;14(4):223-7. doi: 10.1007/BF01219420.
9
C-peptide immunoreactivity (CPR) in urine.尿中C肽免疫反应性（CPR）
Diabetes. 1978;27 Suppl 1:210-5. doi: 10.2337/diab.27.1.s210.
10
Persistent insulin secretion, assessed by plasma C-peptide estimation in long-term juvenile diabetics with a low insulin requirement.通过对胰岛素需求量低的长期青少年糖尿病患者进行血浆C肽评估来测定持续性胰岛素分泌。
Diabetologia. 1978 Sep;15(3):169-72. doi: 10.1007/BF00421234.