Schnitzler L, Baran R, Verret J L
Ann Dermatol Venereol. 1980 Aug-Sep;107(8-9):777-85.
30 specimens of nail fold biopsies have been studied through light and electron microscopy, and direct immunofluorescence, in 26 cases of connective tissue diseases: Raynaud's phenomenon and acrosclerosis (7 cases), systemic scleroderma (10 cases), chronic and acute lupus erythematosus (4 cases), dermatomyositis (5 cases). Numerous tissular changes have been observed by these three different ways: capillaries dilatations, dermal sclerosis, numerous, large, dermal and epidermal colloid bodies, basal lamina replications, collagen's modifications, tubuloreticular inclusions, crystalloid bodies, lysosomial inclusions, immunoglobulins deposits. Thus proximal nail fold appears to be an elective tissular area for collagen diseases study.
通过光学显微镜、电子显微镜以及直接免疫荧光法，对26例结缔组织病患者的30份甲襞活检标本进行了研究，这些疾病包括雷诺现象和肢端硬化症（7例）、系统性硬化症（10例）、慢性和急性红斑狼疮（4例）、皮肌炎（5例）。通过这三种不同方法观察到了许多组织学变化：毛细血管扩张、真皮硬化、大量大的真皮和表皮胶体小体、基底膜重复、胶原蛋白改变、管网状包涵体、晶体小体、溶酶体包涵体、免疫球蛋白沉积。因此，近端甲襞似乎是研究胶原疾病的一个理想组织区域。
