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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Kilcoyne M M, Hoffman D L, Zimmerman E A

Clin Sci (Lond). 1980 Dec;59 Suppl 6:57s-60s. doi: 10.1042/cs059057s.

By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior pituitary gland in the rat. 2. Like vasopressin and its neurophysin, but not oxytocin, ANG II was also found in parvocellular neurons in the suprachiasmatic nucleus. 3. Analysis of these peptides in the same magnocellular neurons reveals that ANG II is localized primarily in vasopressin cells. 4. Like vasopressin and its precursor, ANG II is deficient in homozygous Brattleboro rats with diabetes insipidus. 5. In adrenalectomized rats increases in vasopressin and its neurophysin in median eminence are associated with increases in ANG II. 6. The data suggest that the ANG II demonstrated shares antigenic determinants with the vasopressin precursor, or is regulated in a similar way to vasopressin in the same neurons.

采用免疫过氧化物酶技术，在大鼠下丘脑视上核和室旁核的许多大细胞神经元的细胞体及其通向正中隆起和垂体后叶的通路中定位到了免疫反应性血管紧张素II（ANG II）。2. 与血管加压素及其神经垂体素一样，但与催产素不同，ANG II也存在于视交叉上核的小细胞神经元中。3. 对同一大细胞神经元中的这些肽进行分析发现，ANG II主要定位于血管加压素细胞中。4. 与血管加压素及其前体一样，ANG II在患有尿崩症的纯合布拉特洛伯大鼠中缺乏。5. 在肾上腺切除的大鼠中，正中隆起中血管加压素及其神经垂体素的增加与ANG II的增加相关。6. 数据表明，所显示的ANG II与血管加压素前体具有共同的抗原决定簇，或者在同一神经元中以与血管加压素类似的方式受到调节。

Kilcoyne M M, Hoffman D L, Zimmerman E A

Clin Sci (Lond). 1980 Dec;59 Suppl 6:57s-60s. doi: 10.1042/cs059057s.

By immunoperoxidase technique, immunoreactive angiotensin II (ANG II) was located in the cell bodies of many magnocellular neurons in the supraoptic and paraventricular nuclei of the hypothalamus and their pathways to median eminence and posterior pituitary gland in the rat. 2. Like vasopressin and its neurophysin, but not oxytocin, ANG II was also found in parvocellular neurons in the suprachiasmatic nucleus. 3. Analysis of these peptides in the same magnocellular neurons reveals that ANG II is localized primarily in vasopressin cells. 4. Like vasopressin and its precursor, ANG II is deficient in homozygous Brattleboro rats with diabetes insipidus. 5. In adrenalectomized rats increases in vasopressin and its neurophysin in median eminence are associated with increases in ANG II. 6. The data suggest that the ANG II demonstrated shares antigenic determinants with the vasopressin precursor, or is regulated in a similar way to vasopressin in the same neurons.

采用免疫过氧化物酶技术，在大鼠下丘脑视上核和室旁核的许多大细胞神经元的细胞体及其通向正中隆起和垂体后叶的通路中定位到了免疫反应性血管紧张素II（ANG II）。2. 与血管加压素及其神经垂体素一样，但与催产素不同，ANG II也存在于视交叉上核的小细胞神经元中。3. 对同一大细胞神经元中的这些肽进行分析发现，ANG II主要定位于血管加压素细胞中。4. 与血管加压素及其前体一样，ANG II在患有尿崩症的纯合布拉特洛伯大鼠中缺乏。5. 在肾上腺切除的大鼠中，正中隆起中血管加压素及其神经垂体素的增加与ANG II的增加相关。6. 数据表明，所显示的ANG II与血管加压素前体具有共同的抗原决定簇，或者在同一神经元中以与血管加压素类似的方式受到调节。