Uribe M, Márquez M A, García-Ramos G, Escobedo V, Murillo H, Guevara L, Lisker R
Dig Dis Sci. 1980 Dec;25(12):924-8. doi: 10.1007/BF01308043.
A controlled cross-over clinical comparison of lactose (50 g twice a day) versus neomycin (3 g/day) plus milk of magnesia, was carried out in ten cirrhotic patients with chronic portal-systemic encephalopathy and documented lactase deficiency. Serial semiquantitative assessments were done including: mental state, asterixis, number connection test, electroencephalogram, and blood ammonia levels. No patient developed deep coma while ingesting either lactose or neomycin plus milk of magnesia. However, a significant improvement of mental state, asterixis, number connection tests, and electroencephalograms was evident during lactose therapy. apart from mild diarrhea and bloating, no severe side effects were noticeable during lactose treatment. Based on these results, we propose lactose as a valuable alternate treatment of portal-systemic encephalopathy in lactase-deficient populations.
对10例患有慢性门体性脑病且有乳糖酶缺乏记录的肝硬化患者进行了一项对照交叉临床比较，比较乳糖（每日两次，每次50克）与新霉素（每日3克）加氧化镁乳剂的疗效。进行了一系列半定量评估，包括：精神状态、扑翼样震颤、数字连接试验、脑电图和血氨水平。在摄入乳糖或新霉素加氧化镁乳剂期间，没有患者出现深度昏迷。然而，在乳糖治疗期间，精神状态、扑翼样震颤、数字连接试验和脑电图有明显改善。除了轻度腹泻和腹胀外，乳糖治疗期间没有明显的严重副作用。基于这些结果，我们建议乳糖作为乳糖酶缺乏人群门体性脑病的一种有价值的替代治疗方法。
