Gunasekaran Uma, Gannon Maureen
Departments of Medicine, Vanderbilt University, Nashville, TN 37232-0475, USA.
Aging (Albany NY). 2011 Jun;3(6):565-75. doi: 10.18632/aging.100350.
The incidence of and susceptibility to Type 2 diabetes increases with age, but the underlying mechanism(s) within beta cells that contribute to this increased susceptibility have not been fully elucidated. Here we review how aging affects the proliferative and regenerative capacity of beta cells and how this impacts beta cell mass. In addition we review changes that occur in beta cell function with age. Although we focus on the different rodent models that have provided insight into the characteristics of the aging beta cell, the limited knowledge from non-rodent models is also reviewed. Further studies are needed in order to identify potential beta cell targets for preventing or slowing the progression of diabetes that occurs with age.
2型糖尿病的发病率和易感性随年龄增长而增加，但β细胞内导致这种易感性增加的潜在机制尚未完全阐明。在此，我们综述衰老如何影响β细胞的增殖和再生能力，以及这如何影响β细胞质量。此外，我们还综述了β细胞功能随年龄发生的变化。尽管我们重点关注了不同的啮齿动物模型，这些模型为了解衰老β细胞的特征提供了见解，但我们也回顾了非啮齿动物模型的有限知识。为了确定预防或减缓随年龄发生的糖尿病进展的潜在β细胞靶点，还需要进一步的研究。
