Christensen N C, Hagen C, Nielsen M D, Petersen S
Acta Endocrinol (Copenh). 1981 Jan;96(1):30-5. doi: 10.1530/acta.0.0960030.
Investigations in a 14 year old girl with arrested growth for 2 years, delayed pubertal development, hypernatraemia without thirst, diabetes mellitus and hyperlipaemia are reported. The hypernatraemia was accompanied by a low vasopressin concentration with an abnormal response to thirst, high plasma renin but normal plasma aldosterone concentrations. Treatment with vasopressin and increased fluid intake decreased serum sodium levels. Serum gonadotrophins were low; GH response during an insulin tolerance test was subnormal and basal serum Prl concentration was elevated. Bone age, thyroid function and adrenal function were normal. After initiation of bromocriptine treatment her growth accelerated and regular menstruations commenced. The serum gonadotrophin levels increased and showed pulsatile release. A hypothalamic disorder is suggested, but no cerebral lesion could be demonstrated.
报告了一名14岁女孩的检查情况，该女孩生长停滞2年，青春期发育延迟，有高钠血症且无口渴感，患有糖尿病和高脂血症。高钠血症伴有低血管加压素浓度、对口渴的异常反应、高血浆肾素但血浆醛固酮浓度正常。使用血管加压素治疗并增加液体摄入量可降低血清钠水平。血清促性腺激素水平低；胰岛素耐量试验期间的生长激素反应低于正常水平，基础血清催乳素浓度升高。骨龄、甲状腺功能和肾上腺功能正常。开始使用溴隐亭治疗后，她的生长加速，月经规律来潮。血清促性腺激素水平升高并呈脉冲式释放。提示存在下丘脑疾病，但未发现脑部病变。
