Ottesen B, Larsen J J, Fahrenkrug J, Stjernquist M, Sundler F
Am J Physiol. 1981 Jan;240(1):E32-6. doi: 10.1152/ajpendo.1981.240.1.E32.
The distribution and concentration of vasoactive intestinal polypeptide (VIP) in different parts of the female genital organs from various species (cat, goat, pig, rabbit, rat, and guinea pig) were studied by means of immunohistochemistry and immunochemistry. In addition, the effect of VIP on the mechanical activity of uterine muscle was investigated in vitro. VIP immunoreactive nerve fibers innervating vessels and smooth muscle cells were fairly numerous in the genital organs of the cat and goat and less numerous in the pig, rabbit, rat, and guinea pig. In all species studied, VIP-containing nerves were most numerous in the cervix. The tissue concentration of VIP measured by immunochemistry was in agreement with the immunohistochemical findings. VIP inhibited the mechanical uterine activity in the cat, goat, pig, and rabbit, whereas only minimal effects were obtained in the rat and guinea pig. This difference between the species corresponded to the number of VIP-containing nerves in the uterine muscle. The data support the hypothesis that VIP may play a physiological role in the local nervous control of the uterine mechanical activity.
采用免疫组织化学和免疫化学方法，研究了血管活性肠肽（VIP）在不同物种（猫、山羊、猪、兔、大鼠和豚鼠）雌性生殖器官不同部位的分布和浓度。此外，还在体外研究了VIP对子宫肌机械活性的影响。支配血管和平滑肌细胞的VIP免疫反应性神经纤维在猫和山羊的生殖器官中相当多，而在猪、兔、大鼠和豚鼠中较少。在所研究的所有物种中，含VIP的神经在子宫颈中最多。通过免疫化学测定的VIP组织浓度与免疫组织化学结果一致。VIP抑制猫、山羊、猪和兔的子宫机械活性，而在大鼠和豚鼠中仅获得最小的作用。物种之间的这种差异与子宫肌中含VIP神经的数量相对应。这些数据支持了VIP可能在子宫机械活性的局部神经控制中发挥生理作用这一假说。
