Bonomi P D, Chandra G, Rossof A H, Klaassen D
Cancer Chemother Pharmacol. 1980;5(1):39-42. doi: 10.1007/BF00578560.
The combination of mitomycin C, methyl-CCNU and 5-fluorouracil produced no objective tumor regressions in 25 evaluable patients with metastatic colorectal carcinoma. Patients who achieved stable disease survived significantly longer than patients who had progressive disease. This difference appeared to be more probably related to pre-treatment characteristics of the patients than caused by treatment. Serial CEA determinations revealed a parallel relationship with tumor behavior in 17 of 19 patients.
丝裂霉素C、甲基环己亚硝脲和5-氟尿嘧啶联合使用，在25例可评估的转移性结直肠癌患者中未产生客观的肿瘤消退。病情稳定的患者比病情进展的患者存活时间显著更长。这种差异似乎更可能与患者的治疗前特征有关，而非由治疗导致。连续测定癌胚抗原（CEA）显示，19例患者中有17例其CEA与肿瘤行为呈平行关系。
