Falkson G, Falkson H C
Cancer. 1976 Oct;38(4):1468-70. doi: 10.1002/1097-0142(197610)38:4<1468::aid-cncr2820380403>3.0.co;2-k.
In a randomized study 91 patients with metastatic cancer of the colon were treated with either fluorouracil alone or a combination of fluorouracil, methyl-CCNU, and vincristine. Of those treated with the three-drug combination, 37% responded, and of those treated with fluorouracil alone, 22% responded. Median response duration for patients treated with the combination method was 5.0 months and for those with fluorouracil alone, 3.8 months. Toxic effects are also compared. From this study it is concluded that a three-drug regimen provides a definite advantage.
在一项随机研究中，91例转移性结肠癌患者接受了单独使用氟尿嘧啶或氟尿嘧啶、甲环亚硝脲和长春新碱联合治疗。接受三联药物组合治疗的患者中，37%有反应，而单独接受氟尿嘧啶治疗的患者中，22%有反应。联合治疗方法的患者中位反应持续时间为5.0个月，单独使用氟尿嘧啶的患者为3.8个月。还比较了毒性作用。从这项研究得出结论，三联药物疗法具有明显优势。
