Fitzpatrick J M, Marberger M, Koh S K, Wickham J E
Eur Urol. 1981;7(1):16-8. doi: 10.1159/000473164.
Kidneys preserved with cold Collins' solution only function satisfactorily if there is no significant preceding period of warm ischaemia. This paper reports an attempt to provide protection to renal function during such a warm ischaemic episode using the nucleotide inosine. In these experiments inosine given intravenously to dogs followed by 15 min of warm renal ischaemia and by either 12 or 24 h of cold preservation with Collins' solution did not protect renal function against the warm ischaemic insult.
仅用冷柯林斯液保存的肾脏，只有在之前没有明显的热缺血期时才会有令人满意的功能。本文报道了一项尝试，即使用核苷酸肌苷在热缺血期间为肾功能提供保护。在这些实验中，给狗静脉注射肌苷，随后进行15分钟的热肾缺血，然后用柯林斯液进行12或24小时的冷保存，结果显示肌苷并不能保护肾功能免受热缺血损伤。
