von Graffenried B, Nüesch E, Maeglin B, Hägler W, Kuhn M
Eur J Clin Pharmacol. 1980 Nov;18(6):479-82. doi: 10.1007/BF00874659.
The usefulness of the dental outpatient model for evaluating the efficacy of mild analgesics, first described by Cooper and Beaver, is demonstrated in five separate, double-blind, randomised, single-dose, parallel-group studies. Pain intensity and pain relief were recorded at hourly intervals for 3 h following the administration of aspirin 1000 mg and placebo. In all five studies aspirin was significantly more effective than placebo, with relatively small variability of the response between the studies. The method is simple, reliable and sensitive and complements the inpatient studies of postoperative pain hitherto more frequently used.
库珀和比弗首次描述的牙科门诊模型在评估轻度镇痛药疗效方面的实用性，在五项独立、双盲、随机、单剂量、平行组研究中得到了证实。在服用1000毫克阿司匹林和安慰剂后，每小时记录一次疼痛强度和疼痛缓解情况，持续3小时。在所有五项研究中，阿司匹林的疗效均显著优于安慰剂，且各研究之间的反应变异性相对较小。该方法简单、可靠且灵敏，对迄今更常用的术后疼痛住院研究起到了补充作用。
