过量产生dam甲基化酶的大肠杆菌K-12克隆具有高度可突变性。
Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.
作者信息
Herman G E, Modrich P
出版信息
J Bacteriol. 1981 Jan;145(1):644-6. doi: 10.1128/jb.145.1.644-646.1981.
Abstract
A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.
摘要
一株过量产生dam甲基化酶达50倍的大肠杆菌K-12菌株被发现具有高度易突变性，导致过量甲基化酶活性丧失的突变使突变频率恢复到野生型水平。这些结果与这种脱氧核糖核酸甲基化酶参与错配修复一致。
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