IgA肾病患者肾组织对补体的激活作用。

Tomino Y, Endoh M, Nomoto Y, Sakai H

J Clin Pathol. 1981 Jan;34(1):35-40. doi: 10.1136/jcp.34.1.35.

In a study of complement activation by renal tissues, renal biopsy specimens were obtained from patients with IgA nephropathy and other glomerular diseases. These specimens were incubated with freshly frozen guinea-pig serum, and the activation of guinea-pig complement systems was evaluated by immunofluorescent staining with FITC-conjugated anti-guinea-pig complement antisera. It was shown that the alternative pathway of the complement was activated in situ in renal tissues from patients with IgA nephropathy. it is suggested that analysis of in situ activation of complement in such patients is useful for elucidating the mechanism of complement activation in various glomerular diseases.

在一项关于肾组织补体激活的研究中，从患有IgA肾病和其他肾小球疾病的患者身上获取肾活检标本。将这些标本与新鲜冷冻的豚鼠血清一起孵育，并用异硫氰酸荧光素（FITC）偶联的抗豚鼠补体抗血清进行免疫荧光染色，以评估豚鼠补体系统的激活情况。结果表明，IgA肾病患者肾组织中的补体替代途径在原位被激活。提示对这类患者补体原位激活情况进行分析，有助于阐明各种肾小球疾病中补体激活的机制。