Jacobs J R, Levine L A, Davis H, Lefrak S S, Druck N S, Ogura J H
Laryngoscope. 1981 Feb;91(2):279-84. doi: 10.1288/00005537-198102000-00017.
Increased mortality and arterial hypoxemia have long been associated with posterior nasal packs placed for control of severe epistaxis. Several authors have postulated a nasopulmonary reflex to partially explain this clinically observed phenomenon. In ten young, healthy subjects, using a multiparameter pulmonary evaluation, posterior nasal packs were placed and no significant changes were observed in lung volumes, flow and alveolar gas exchange, especially oxygenation. These findings suggest that aspiration, sedation, and degeneration of pulmonary function with age, not a nasopulmonary reflex, have not been adequately emphasized in previously performed studies.
长期以来，因控制严重鼻出血而放置后鼻孔填塞物与死亡率增加和动脉血氧不足有关。几位作者推测存在鼻肺反射，以部分解释这一临床观察到的现象。在10名年轻健康受试者中，通过多参数肺功能评估，放置后鼻孔填塞物后，肺容量、流量和肺泡气体交换，尤其是氧合方面未观察到显著变化。这些发现表明，在先前的研究中，未充分强调误吸、镇静以及肺功能随年龄衰退，而非鼻肺反射。
