Feingold J, Bois E, Lallemant M, Feingold N
Rev Epidemiol Sante Publique. 1980 Apr 30;28(1):39-46.
Geographical variation in the incidence of an Anencephaly and Spina-Bifida is well documented. The highest rates for these malformations were found in Ireland, Wales, Scotland and in Western regions of England. These rates decrease progressively towards eastern Europe. In France the highest rates were found in some regions of Brittany. The geographical correlations between the mortality rates of Spina-Bifida and incidence of Spina-Bifida and Anencephaly and the HLA antigen frequencies are studied. There is a positive correlation with A1 and B8 and a negative one with B5 and BW35. The role of the HLA system in these associations is discussed.
无脑儿和脊柱裂发病率的地理差异已有充分记录。这些畸形的最高发病率出现在爱尔兰、威尔士、苏格兰以及英格兰西部地区。这些发病率朝着东欧方向逐渐降低。在法国，布列塔尼的一些地区发病率最高。对脊柱裂死亡率与脊柱裂和无脑儿发病率以及HLA抗原频率之间的地理相关性进行了研究。发现与A1和B8呈正相关，与B5和BW35呈负相关。讨论了HLA系统在这些关联中的作用。
