Arnold R, Pflieger H, Wiesneth M, Bhaduri S, Bültmann B, Heimpel H
Scand J Haematol. 1981 Jan;26(1):31-6. doi: 10.1111/j.1600-0609.1981.tb01620.x.
The in vitro function of granulocytes collected by filtration leukapheresis after premedication of donors with dexamethasone was found to be normal. In vivo studies were performed in a 21-year-old woman who was transplanted with allogeneic bone marrow for severe aplastic anaemia. The patient received granulocyte transfusions for treatment of septicaemia during the transplantation period. On 11 consecutive days an average dose of 7.2 X 10(10) granulocytes/transplantation, the patient died from cardiac failure. Transfused granulocytes were found ante mortem in a pericardial effusion and post mortem in lungs, kidneys, liver and spleen. The data indicate that filter collected granulocytes function normally in the recipient and are clinically effective.
在供体用地塞米松预处理后通过过滤白细胞去除术采集的粒细胞的体外功能被发现是正常的。在一名因严重再生障碍性贫血接受异基因骨髓移植的21岁女性身上进行了体内研究。该患者在移植期间接受粒细胞输注以治疗败血症。连续11天，平均每次移植剂量为7.2×10¹⁰个粒细胞，患者死于心力衰竭。在死前的心包积液中发现了输注的粒细胞，死后在肺、肾、肝和脾中也发现了。数据表明，通过过滤采集的粒细胞在受者体内功能正常且临床有效。
