Balkwill F, Watling D, Taylor-Papadimitriou J
Int J Cancer. 1978 Sep 15;22(3):258-65. doi: 10.1002/ijc.2910220307.
Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth potential of cells at lower density in colony-forming cultures was not completely recovered. Studies on the cell cycle distribution of interferon-treated cells demonstrated that the growth-inhibitory effect was not due to an effect on one specific phase of the cell cycle, but to a lengthening of all phases.
人淋巴母细胞干扰素抑制来自正常、增生性和肿瘤性人乳腺组织的成纤维细胞和上皮细胞的体外生长。在每毫升10³国际单位（IU）的干扰素浓度下，对单层生长的抑制作用是完全可逆的，但在集落形成培养物中较低密度细胞的生长潜力并未完全恢复。对干扰素处理细胞的细胞周期分布研究表明，生长抑制作用并非由于对细胞周期某一特定阶段的影响，而是由于所有阶段的延长。
