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干扰素对人克隆细胞系RSa的作用：对大分子合成的抑制

Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis.

作者信息

Fuse A, Kuwata T

出版信息

J Gen Virol. 1976 Oct;33(1):17-24. doi: 10.1099/0022-1317-33-1-17.

DOI:10.1099/0022-1317-33-1-17
PMID:978184
Abstract

Multiplication of the human clonal cell line, RSa, is completely inhibited by human leukocyte interferon preparations. Synthesis of DNA and protein is markedly reduced in these cells in proportion to the concentration of interferon applied. Interferon treatment leads to accumulation of cells of an epithelial morphology which do not enter the division cycle. It is suggested that the growth inhibitory effects of interferon on RSa cells may result from these effects.

摘要

人克隆细胞系RSa的增殖完全受到人白细胞干扰素制剂的抑制。这些细胞中DNA和蛋白质的合成与所应用的干扰素浓度成比例地显著减少。干扰素处理导致上皮形态的细胞积累，这些细胞不进入分裂周期。有人认为，干扰素对RSa细胞的生长抑制作用可能源于这些效应。

相似文献

1
Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis.干扰素对人克隆细胞系RSa的作用：对大分子合成的抑制
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Jpn J Cancer Res. 1995 Aug;86(8):761-9. doi: 10.1111/j.1349-7006.1995.tb02466.x.
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Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis.β干扰素对不同群体倍增水平的人成纤维细胞的影响。增殖、细胞体积、胸苷摄取及DNA合成。
J Exp Med. 1984 Jun 1;159(6):1741-9. doi: 10.1084/jem.159.6.1741.
3
Interferon effects on multiplication, cytoplasmic protein and GFAP content, and morphology in human glioma cells.
干扰素对人胶质瘤细胞增殖、细胞质蛋白和胶质纤维酸性蛋白含量以及形态的影响。
J Neurooncol. 1983;1(1):69-76. doi: 10.1007/BF00153644.
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Interferon increases HLA synthesis in melanoma cells: interferon-resistant and -sensitive cell lines.
Proc Natl Acad Sci U S A. 1982 May;79(10):3265-9. doi: 10.1073/pnas.79.10.3265.
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Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts.干扰素对人成纤维细胞微丝组织、细胞纤连蛋白分布及细胞运动性的影响。
J Cell Biol. 1980 Apr;85(1):9-17. doi: 10.1083/jcb.85.1.9.
6
Regulation of cell proliferation and differentiation by interferons.干扰素对细胞增殖和分化的调控。
Biochem J. 1985 Mar 1;226(2):345-60. doi: 10.1042/bj2260345.
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Inhibition of cell proliferation by interferons. Relative contributions of changes in protein synthesis and breakdown to growth control of human lymphoblastoid cells.干扰素对细胞增殖的抑制作用。蛋白质合成与分解的变化对人淋巴母细胞生长控制的相对贡献。
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Radioprotective activity of interferon inducers.干扰素诱导剂的辐射防护活性。
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