Budd R D
Clin Toxicol. 1981 Jul;18(7):773-82. doi: 10.3109/15563658108990304.
Twenty-seven different cocaine-related substances were analyzed by radioimmunoassay (RIA) at several concentrations. An attempt was made to relate structural differences to the affinity of the compounds with the RIA benzoylecgonine (cocaine metabolite) antibody. The effects of substituent placement in the cocaine molecule were studied. Adding an alkyl group to the 2-carboxylic acid (conversion to an alkyl ester) increased reactivity, whereas changes in all other positions reduced reactivity.
通过放射免疫分析法（RIA）对27种不同的可卡因相关物质在几种浓度下进行了分析。试图将结构差异与这些化合物对RIA苯甲酰芽子碱（可卡因代谢物）抗体的亲和力联系起来。研究了可卡因分子中取代基位置的影响。在2-羧酸上添加一个烷基（转化为烷基酯）会增加反应活性，而其他所有位置的变化都会降低反应活性。
