Budd R D, Leung W J, Yang F C
Clin Toxicol. 1980 Oct;17(3):383-93. doi: 10.3109/15563658008989987.
Twenty-six different opiates were analyzed by radioimmunoassay (RIA) at five different concentrations. At attempt is made to relate structural differences to the affinity of the compounds for the Roche RIA morphine antibody. The effects of substituent placement on the morphine molecule are studied. As expected, the basic 5-ring opiate structure is essential for reactivity. Addition of an alkyl group to the oxygen in the 3-position increased affinity, but alteration of other key functional groups had a reverse affect.
采用放射免疫分析法（RIA）对26种不同的阿片类药物在5种不同浓度下进行了分析。试图将结构差异与这些化合物对罗氏RIA吗啡抗体的亲和力联系起来。研究了取代基在吗啡分子上的位置所产生的影响。正如预期的那样，基本的五环阿片类结构对于反应活性至关重要。在3位的氧原子上添加一个烷基会增加亲和力，但其他关键官能团的改变则产生相反的效果。
